Three of the 11 finalists in UConn’s 3-minute thesis competition were graduate students in Pharmaceutics Program. This year’s winner, Shipra Malik, is a CPPR student from Dr. Raman Bahal’s lab. Click on https://grad.uconn.edu/2021/08/17/uconns-3mt-winners-2021/ to see Shipra’s winning video. This is the second time a CPPR student has won the UConn 3MT competition. In 2019, Koyel Sen of Bodhi Chaudhuri’s lab was the topper.
CPPR Project Elucidates the Risk Factors Related to Residual Crystallinity in Amorphous Solid Dispersions
DanaMoseson and her advisor, Lynne Taylor, from PurdueUniversity published their findings on the effect of residual crystallinity on the loss of the solubility advantage of ASDs in a paper in European Journal of Pharmaceutical Sciences. Read more at https://doi.org/10.1016/j.ejps.2020.105276
CPPR Project Identifies Key Factors Governing the Reconstitution of Lyophilized Protein
@ShreyaKulkarni, along with her advisor, @RobinBogner from @UConnPharmacy, and @RajSury from @University of Minnesota College of Pharmacy and CPPR mentors, @SajalPatel and @Joseph Rinella published their findings on what causes long reconstitution times in high concentration proteins. Read more at https://doi.org/10.1016/j.ejpb.2021.05.005
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Pediatric Mini-Tablet Formulation Explored Using Juvenile Porcine Model in CPPR Project
CPPR student, Monika Lavan, along with her mentor Greg Knipp and fellow CPPR faculty, Stephen Byrn of Purdue University and CPPR industrial mentor, Scott Hostetler, published their findings on the pharmacokinetics of a pediatric mini-tablet formulation of lapatinib evaluated in the mini-pig model. See https://doi.org/10.1208/s12249-020-01891-x to read more.
CPPR Project Finds Factors Influencing Stability of Biologics Stored in Bottles
@Bruna Minatovicz (under the supervision of her doctoral mentor, @Bodhi Chaudhuri, from @UConnPharmacy) published their findings on the factors that influence the stability of a model enzyme during bulk freezing. Fill volume, storage placement, and cooling rate were shown to be significant factors. See more at https://doi.org/10.1208/s12249-021-02034-6 in @AAPSPharmSciTech.
CPPR Semi-Annual Spring Scientific Conference is a Virtual Success
Eighty-eight scientists from 9 companies and 3 universities met virtually on May 24 and 25 to share findings on completed projects, updates on current research and proposals on new research. Final project reports were in the areas of 3D printing, tabletability, oral peptide delivery, and modeling of tablet disintegration and dissolution. Project updates were presented by poster on lyophilized formulations, continuous manufacturing, modeling of fluid bed drying, nanoparticle freeze-drying, and imaging of lyophilized products. Proposed areas of research included binder-excipient interactions, predicting oral absorption, monitoring protein structural changes, excipient impact on protein formulations.
CPPR Student Awarded at the 2021 RNA Institute Mini-Symposium
CPPR student, Shipra Malik’s abstract was selected for an oral presentation and an award for the prestigious “2021 RNA Institute Mini-Symposium series” at University at Albany, SUNY.
Raman Bahal Receives 2021 Early Career Award at UConn
Dr. Raman Bahal, Assistant Professor of Pharmaceutics at UConn was selected for the Early Career Award in the 2021 Excellence in Research and Creativity Program. Read more at UConn Today Raman Bahal Selected for AAUP Excellence Award – UConn Today
CPPR Faculty, Prof. Diane J Burgess, Launches New Company and Licenses UConn Technology
Diane Burgess and Antonio Costa co-founded DIANT Pharma Inc in 2019 and recently licensed technology for the continuous manufacturing of nanoparticulate drug delivery systems. Read more at https://today.uconn.edu/2020/11/uconn-diant-pharma-licenses-continuous-manufacturing-nanoparticle-system/ .
Rank Order of Drug Tabletability Can Change When Excipients are Added
The results of another CPPR project have been published in December issue of the Journal of Pharmaceutical Sciences. CPPR Faculty, Changquan Calvin Sun, of University of Minnesota and his group showed the change in order of tabletability of three drug powders by the addition of microcrystalline cellulose. https://doi.org/10.1016/j.xphs.2020.09.005