@Bruna Minatovicz (under the supervision of her doctoral mentor, @Bodhi Chaudhuri, from @UConnPharmacy) published their findings on the factors that influence the stability of a model enzyme during bulk freezing.  Fill volume, storage placement, and cooling rate were shown to be significant factors.  See more at https://doi.org/10.1208/s12249-021-02034-6 in @AAPSPharmSciTech. 

 

Eighty-eight scientists from 9 companies and 3 universities met virtually on May 24 and 25 to share findings on completed projects, updates on current research and proposals on new research. Final project reports were in the areas of 3D printing, tabletability, oral peptide delivery, and modeling of tablet disintegration and dissolution.  Project updates were presented by poster on lyophilized formulations, continuous manufacturing, modeling of fluid bed drying, nanoparticle freeze-drying, and imaging of lyophilized products.  Proposed areas of research included binder-excipient interactions, predicting oral absorption, monitoring protein structural changes, excipient impact on protein formulations.