@Bruna Minatovicz (under the supervision of her doctoral mentor, @Bodhi Chaudhuri, from @UConnPharmacy) published their findings on the factors that influence the stability of a model enzyme during bulk freezing. Fill volume, storage placement, and cooling rate were shown to be significant factors. See more at https://doi.org/10.1208/s12249-021-02034-6 in @AAPSPharmSciTech.